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Topoisomerase II inhibitor 7

Selected Variant

HY-146163

Size: 1 Each

Topoisomerase II inhibitor 7 (compound 3a) is a potent inhibitor of topoisomerase II alpha subtype, with an IC50 of 3.19 μM. Topoisomerase II inhibitor 7 can induce cell cycle arrest and apoptosis[1].

Product Specifications

CAS Number

2697171-03-0

UNSPSC

12352005

Target

Apoptosis; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-ii-inhibitor-7.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C2=CC=CC=C2)N=C3SC4=C(N3C1C5=CC(OC)=C(C(OC)=C5)OC)N=C(N)N=C4C6=CC=C(Br)C=C6)OCC

Molecular Formula

C32H28BrN5O5S

Molecular Weight

674.56

References & Citations

[1]Nemr MTM, et, al. Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II: Molecular docking and apoptosis inducing activity. Bioorg Chem. 2020 Dec;105:104446.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Topo II

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