TRPC4/5-IN-1

TRPC4/5-IN-1 is a potent TRP channel 4/5 (TRPC4/5) inhibitor with IC50s of 2.06 μM and 0.54 μM, respectively. TRPC4/5-IN-1 can be used for proteinuric kidney diseases and skin inflammatory diseases research[1].

Product Specifications

CAS Number

3032263-08-1

UNSPSC

12352005

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/trpc4-5-in-1.html

Solubility

10 mM in DMSO

Smiles

CCC1=CC=C(N(CC2=CC=CC=C2)C(NCC3=CC=CO3)=N4)C4=C1

Molecular Formula

C21H21N3O

Molecular Weight

331.41

References & Citations

[1]Lili Chen, et al. Synthesis of AC1903 analogs as potent transient receptor potential canonical channel 4/5 inhibitors and biological evaluation. Bioorg Med Chem. 2022 May 27;68:116853.