γ-Secretase modulator 12
γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM) . γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice[1].
Product Specifications
CAS Number
2204249-82-9
UNSPSC
12352005
Target
Amyloid-β; γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/γ-secretase-modulator-12.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(CN1CC)C=C(C3=C(C)N=C4C(OCC5=CC=CC=C5)=CC=CN43)C=C2
Molecular Formula
C25H23N3O2
Molecular Weight
397.47
References & Citations
[1]Ryuichi Sekioka, et al. Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators. Bioorg Med Chem. 2020 Jan 1;28 (1) :115132.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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