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Kolavenic acid analog

Kolavenic acid analog (KAA) is an anticancer agent. Kolavenic acid analog shows strong activity against HSET-overproducing yeast cells. Kolavenic acid analog inhibits centrosome clustering in human cancer cells containing high HSET levels and supernumerary centrosomes[1].

Product Specifications

CAS Number

[2379777-37-2]

Product Name Alternative

KAA

UNSPSC

12352211

Target

Kinesin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kolavenic-acid-analog.html

Solubility

10 mM in DMSO

Smiles

O=C(O)/C=C(C)/CC[C@]1(C)[C@H](C)C[C@@H](OC(/C(C)=C/C)=O)[C@@]2(C)C(C)=CCC[C@@]12[H]

Molecular Formula

C25H38O4

Molecular Weight

402.57

References & Citations

[1]Kurisawa N, et al. Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells. Bioorg Med Chem. 2020 Jan 1;28 (1) :115154.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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