Kolavenic acid analog
Kolavenic acid analog (KAA) is an anticancer agent. Kolavenic acid analog shows strong activity against HSET-overproducing yeast cells. Kolavenic acid analog inhibits centrosome clustering in human cancer cells containing high HSET levels and supernumerary centrosomes[1].
Product Specifications
CAS Number
2379777-37-2
Product Name Alternative
KAA
UNSPSC
12352211
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kolavenic-acid-analog.html
Solubility
10 mM in DMSO
Smiles
O=C(O)/C=C(C)/CC[C@]1(C)[C@H](C)C[C@@H](OC(/C(C)=C/C)=O)[C@@]2(C)C(C)=CCC[C@@]12[H]
Molecular Formula
C25H38O4
Molecular Weight
402.57
References & Citations
[1]Kurisawa N, et al. Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells. Bioorg Med Chem. 2020 Jan 1;28 (1) :115154.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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