AChE/BuChE-IN-2
AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB[1].
Product Specifications
CAS Number
1946008-31-6
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-buche-in-2.html
Solubility
10 mM in DMSO
Smiles
C1(C2=CC=C(OCO3)C3=C2)=NC4=CC=CC=C4C(N5CCCC5)=C1
Molecular Formula
C20H18N2O2
Molecular Weight
318.37
References & Citations
[1]Luo W, et al. Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents. Bioorg Med Chem. 2020 Jan 1;28 (1) :115190.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
Frequently Asked Questions
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