AChE/BuChE-IN-2

AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB[1].

Product Specifications

CAS Number

[1946008-31-6]

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-buche-in-2.html

Solubility

10 mM in DMSO

Smiles

C1(C2=CC=C(OCO3)C3=C2)=NC4=CC=CC=C4C(N5CCCC5)=C1

Molecular Formula

C20H18N2O2

Molecular Weight

318.37

References & Citations

[1]Luo W, et al. Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents. Bioorg Med Chem. 2020 Jan 1;28 (1) :115190.