Aβ-IN-4
Aβ-IN-4 (compound 12) is a potent amyloid β (Aβ) inhibitor. Aβ-IN-4 inhibits Aβ42 aggregation. However, Aβ-IN-4 can not alleviate the neurotoxicity of Aβ42 in SH-SY5Y cells. Aβ-IN-4 can not change the aggregation state of Aβ42 into a nontoxic one[1].
Product Specifications
CAS Number
2477606-97-4
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aβ-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CC1=CC=C(OC/C=C/C[C@@H](C(N2)=O)NC([C@@H](N)CC(C)C)=O)C=C1)C(N[C@@H](C)C(O)=O)=O)[C@@H]2CC3=CC=CC=C3
Molecular Formula
C33H43N5O7
Molecular Weight
621.72
References & Citations
[1]Tanaka F, et al. Design and synthesis of β-strand-fixed peptides inhibiting aggregation of amyloid β-protein. Bioorg Med Chem. 2020 Sep 15;28 (18) :115676.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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