EGFR-IN-57
EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR-TK inhibitor with an IC50 of 0.054 µM. EGFR-IN-57 also inhibits VEGFR-2, CK2α, topoisomerase IIβ and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13 and 3.61 µM, respectively. EGFR-IN-57 induces cell cycle arrest at G2/M and pre-G1 phases. EGFR-IN-57 induces cancer cell apoptosis[1].
Product Specifications
CAS Number
2492382-37-1
UNSPSC
12352005
Target
Apoptosis; Casein Kinase; EGFR; Microtubule/Tubulin; Topoisomerase; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-57.html
Solubility
10 mM in DMSO
Smiles
O=C1N=C(NC2=NOC(C)=C2)S/C1=C\C3=C4C=CC=CC4=CC5=CC=CC=C35
Molecular Formula
C22H15N3O2S
Molecular Weight
385.44
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK2; EGFR/ErbB1/HER1; Topo II; VEGFR2/KDR/Flk-1
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