Tau-aggregation-IN-1
Tau-aggregation-IN-1 (Compound D-519) is a tau441 protein aggregation inhibitor with an IC50 of 21 µM. Tau-aggregation-IN-1 is also a dopamine D2 and D3 receptor agonist[1].
Product Specifications
CAS Number
1619269-19-0
UNSPSC
12352005
Target
Dopamine Receptor; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tau-aggregation-in-1.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1C(C=C2)=CC=C2N(CC3)CCN3CCN([C@H]4CC5=C(N=C(S5)N)CC4)CCC)=C(C=C1)O
Molecular Formula
C28H37N5O2S
Molecular Weight
507.69
References & Citations
[1]Iva Ziu, et al. The multifunctional dopamine D2/D3 receptor agonists also possess inhibitory activity against the full-length tau441 protein aggregation. Bioorg Med Chem. 2020 Sep 15;28 (18) :115667.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor; D3 Receptor
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