EGFR-IN-55

EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity[1].

Product Specifications

CAS Number

[2057423-46-6]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-55.html

Solubility

10 mM in DMSO

Smiles

C=C(Cl)C(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3)=NC=C2Cl)=C1)=O

Molecular Formula

C25H25Cl2N7O2

Molecular Weight

526.42

References & Citations

[1]Shao J, et al. Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M. Bioorg Med Chem. 2020 Oct 1;28 (19) :115680.