Grb2 SH2 domain inhibitor 1
Grb2 SH2 domain inhibitor 1 is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.
Product Specifications
UNSPSC
12352209
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/grb2-sh2-domain-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
CC([C@@H]1NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H]3CCCN3C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CC(N)=O)=O)CC4=CC=CC=C4)=O)CC5=CC=C6C=CC=CC6=C5)=O)CCCNC(N)=N)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC7=CC=C(C=C7)OP(O)(O)=O)=O)C
Molecular Formula
C68H95N20O15P
Molecular Weight
1463.58
References & Citations
[1]Wen J, et al. Rational design of cell-permeable cyclic peptides containing a d-Pro-l-Pro motif. Bioorg Med Chem. 2020 Oct 15;28 (20) :115711.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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