ATX inhibitor 20
ATX inhibitor 20 (compound 24) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.3 nM[1].
Product Specifications
CAS Number
2691937-03-6
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atx-inhibitor-20.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC2=C(N(CC)C=C2NC(NCC3=CC=C(F)C=C3)=O)C=C1)C4=CC=C(CN5CCC(O)CC5)C=C4
Molecular Formula
C31H34FN5O3
Molecular Weight
543.63
References & Citations
[1]Jia F, et al. Structure-based linker exploration: Discovery of 1-ethyl-1H-indole analogs as novel ATX inhibitors. Bioorg Med Chem. 2020 Nov 15;28 (22) :115795.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Autotaxin
Frequently Asked Questions
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