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ATX inhibitor 19

ATX inhibitor 19 (compound 22) is a potent ATX (autotaxin) inhibitor, with an IC50 of 156 nM[1].

Product Specifications

CAS Number

2691937-01-4

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/atx-inhibitor-19.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CN(CC)C2=C1C=C(C3=NC(CN4CCN(CCO)CC4)=CS3)C=C2)NCC5=CC=C(Cl)C=C5

Molecular Formula

C28H33ClN6O2S

Molecular Weight

553.12

References & Citations

[1]Jia F, et al. Structure-based linker exploration: Discovery of 1-ethyl-1H-indole analogs as novel ATX inhibitors. Bioorg Med Chem. 2020 Nov 15;28 (22) :115795.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Autotaxin

Frequently Asked Questions

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