TRK-IN-19

TRK-IN-19 (Compound I-10) is a potent inhibitor of TRK (TRKA IC50 = 1.1 nM, TRKAG595R IC50 = 5.3 nM) . TRK-IN-19 has the potential for the research of cancer diseases[1].

Product Specifications

UNSPSC

12352005

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/trk-in-19.html

Solubility

10 mM in DMSO

Smiles

COC1CCC(CC1)NC(C2=C3N=C(C=CN3N=C2)N(CC4=CC(F)=CC=C4)C)=O

Molecular Formula

C22H26FN5O2

Molecular Weight

411.47

References & Citations

[1]Sun M, et al. Design, synthesis and biological activity of bicyclic carboxamide derivatives as TRK inhibitors. Bioorg Med Chem. 2020 Dec 1;28 (23) :115811. doi: 10.1016/j.bmc.2020.115811.