TRK-IN-19
TRK-IN-19 (Compound I-10) is a potent inhibitor of TRK (TRKA IC50 = 1.1 nM, TRKAG595R IC50 = 5.3 nM) . TRK-IN-19 has the potential for the research of cancer diseases[1].
Product Specifications
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trk-in-19.html
Solubility
10 mM in DMSO
Smiles
COC1CCC(CC1)NC(C2=C3N=C(C=CN3N=C2)N(CC4=CC(F)=CC=C4)C)=O
Molecular Formula
C22H26FN5O2
Molecular Weight
411.47
References & Citations
[1]Sun M, et al. Design, synthesis and biological activity of bicyclic carboxamide derivatives as TRK inhibitors. Bioorg Med Chem. 2020 Dec 1;28 (23) :115811. doi: 10.1016/j.bmc.2020.115811.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA
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