Antitumor agent-67

Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity[1].

Product Specifications

CAS Number

[2820146-10-7]

UNSPSC

12352005

Target

Microtubule/Tubulin; Quinone Reductase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-67.html

Solubility

10 mM in DMSO

Smiles

O=C(OCC1=CC=C(N(C)C(CC(C2=C(C)C(C(C)=C(C)C2=O)=O)(C)C)=O)C=C1)O[C@H]3[C@]4([H])[C@@](C(OC4)=O)([H])[C@H](C5=CC(OC)=C(OC)C(OC)=C5)C6=C3C=C7OCOC7=C6

Molecular Formula

C45H47NO13

Molecular Weight

809.85

References & Citations

[1]Qu Y, et al. Synthesis and biological evaluation of NQO1-activated prodrugs of podophyllotoxin as antitumor agents. Bioorg Med Chem. 2020;28 (24) :115821.