GABAA receptor agent 8

GABAA receptor agent 8 (compoud 5e) is a potent GABAA receptor positive modulator. GABAA receptor agent 8 shows anticonvulsant activity in vitro and in vivo with low neurotoxicity. GABAA receptor agent 8 has the potential for the research of epilepsy[1].

Product Specifications

CAS Number

[2376841-54-0]

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gabaa-receptor-agent-8.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C(CC2=CC=CC=C2)N=C3N1NC(C4=CC=C(C)C=C4)=N3

Molecular Formula

C19H16N4O

Molecular Weight

316.36

References & Citations

[1]Huang L, et al. Discovery of [1,2,4]-triazolo [1,5-a]pyrimidine-7 (4H) -one derivatives as positive modulators of GABAA1 receptor with potent anticonvulsant activity and low toxicity. Eur J Med Chem. 2020 Jan 1;185:111824.