RMS5
RMS5, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS5 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS5 slightly diminishes the expression of the anti-apoptotic Bcl-2 family proteins Bcl-XL and Mcl-1. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS5 has strong anticancer property[1].
Product Specifications
CAS Number
2497686-68-5
UNSPSC
12352005
Target
Apoptosis; P-glycoprotein
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rms5.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC(C=C([C@@]2([H])CC3=CC=C(C=C3)O4)C(CCN2C)=C5)=C5OC)C([C@]6([H])CC7=CC4=CS7)=C(CCN6C)C=C1OC
Molecular Formula
C35H38N2O5S
Molecular Weight
598.75
References & Citations
[1]RamonaSchütz, et al. Synthesis, biological evaluation and toxicity of novel tetrandrine analogues. Eur J Med Chem. 2020 Dec 1;207:112810.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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