RMS3

RMS3, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS3 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS3 has strong anticancer property[1].

Product Specifications

CAS Number

[2497686-66-3]

UNSPSC

12352005

Target

Apoptosis; P-glycoprotein

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rms3.html

Solubility

10 mM in DMSO

Smiles

COC1=C2C3=C(C=C1OC)CCN(C)[C@@]3([H])CC4=CC=C(OC(F)(F)F)C(OC5=CC=C(C[C@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4

Molecular Formula

C38H39F3N2O6

Molecular Weight

676.72

References & Citations

[1]RamonaSchütz, et al. Synthesis, biological evaluation and toxicity of novel tetrandrine analogues. Eur J Med Chem. 2020 Dec 1;207:112810.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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