Antitumor agent-62

Antitumor agent-62 (Compound 47) is a NO-releasing antitumor agent. Antitumor agent-62 shows antiproliferative activity against four cancer cell lines. Antitumor agent-62 activates mitochondrial apoptosis pathway and arrests cell cycle at G2/M phase[1].

Product Specifications

CAS Number

[2460735-29-7]

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-62.html

Solubility

10 mM in DMSO

Smiles

O=C1OC2=C(C=C1N)C=C(OC)C(OCCCOC3=NO[N+]([O-])=C3S(=O)(C4=CC=CC=C4)=O)=C2

Molecular Formula

C21H19N3O9S

Molecular Weight

489.46

References & Citations

[1]Shi Z, et al. Novel NO-releasing scopoletin derivatives induce cell death via mitochondrial apoptosis pathway and cell cycle arrest. Eur J Med Chem. 2020 Aug 15;200:112386.