PCSK9 modulator-4
PCSK9 modulator-4 (Compound 21) is a potent modulator of PCSK9 with an EC50 value of 0.15 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C) . PCSK9 modulator-4 has the potential for the research of hyperlipidemia[1].
Product Specifications
CAS Number
2476490-20-5
UNSPSC
12352005
Target
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pcsk9-modulator-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CNC2=C1C=CC=C2F)C3=NC4=CC=C(F)C=C4N3C
Molecular Formula
C17H11F2N3O
Molecular Weight
311.29
References & Citations
[1] Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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