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PCSK9 modulator-3

PCSK9 modulator-3 (Compound 13) is a potent modulator of PCSK9 with an EC50 value of 2.46 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C) . PCSK9 modulator-3 has the potential for the research of hyperlipidemia[1].

Product Specifications

CAS Number

2476490-18-1

UNSPSC

12352005

Target

PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pcsk9-modulator-3.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NC2=CC=C(F)C=C2N1)C3=CNC4=C3C=CC=C4F

Molecular Formula

C16H9F2N3O

Molecular Weight

297.26

References & Citations

[1]Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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