(Z) -p-cyano-α-Cyanostilbene

(Z) -p-cyano-α-Cyanostilbene (compound 11), a phenantrene derivative, has antiproliferative activity. (Z) -p-cyano-α-Cyanostilbene shows significant selectivity against HeLa (IC50=0.21 µM) and HepG2 (IC50=0.230 µM) cells without cytotoxic against normal skin fibroblasts (IC50>100 µM) [1].

Product Specifications

CAS Number

[54676-54-9]

UNSPSC

12352005

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-p-cyano-α-cyanostilbene.html

Solubility

10 mM in DMSO

Smiles

N#C/C(C1=CC=C(C=C1)C#N)=C\C2=CC=CC=C2

Molecular Formula

C16H10N2

Molecular Weight

230.26

References & Citations

[1]Nataša Perin, et al. Antiproliferative activity and mode of action analysis of novel amino and amido substituted phenantrene and naphtho[2,1-b]thiophene derivatives. Eur J Med Chem. 2020 Jan 1;185:111833.