5-HT6/5-HT2A receptor ligand-1
5-HT6/5-HT2A receptor ligand-1 (compound 33) is a dual 5-HT6/5-HT2A receptor antagonist, with a Ki of 2 nM and 11 nM, respectively. 5-HT6/5-HT2A receptor ligand-1 has the potential for neurological and psychiatric disorders research[1].
Product Specifications
CAS Number
2411088-07-6
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-ht6-5-ht2a-receptor-ligand-1.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C2=CC=C(CNCCC3=CNC4=C3C=C(F)C=C4)O2)C=C1
Molecular Formula
C21H19FN2O2
Molecular Weight
350.39
References & Citations
[1]Staroń J, et, al. Virtual screening-driven discovery of dual 5-HT 6/5-HT 2A receptor ligands with pro-cognitive properties. Eur J Med Chem. 2020 Jan 1;185:111857.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor;5-HT6 Receptor; MUC2; α-1 microglobulin
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