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IRAK4-IN-11

IRAK4-IN-11 (compound 6) is a potent IRAK4 inhibitor with an IC50 of 0.008 µM. IRAK4-IN-11 shows cell pIRAK4 potencies with an IC50 of 0.19 µM[1].

Product Specifications

CAS Number

3032742-74-5

UNSPSC

12352005

Target

IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/irak4-in-11.html

Solubility

10 mM in DMSO

Smiles

CN1C=C(C=N1)NC2=NC3=C(C(NC4(CC4)C)=N2)C(N(C=C3)C)=O

Molecular Formula

C16H19N7O

Molecular Weight

325.37

References & Citations

[1]Cumming IA, et al. Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors. Bioorg Med Chem. 2022 Jun 1;63:116729.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IRAK4

Frequently Asked Questions

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