Antiparasitic agent-2

Antiparasitic agent-2 (compound 8a) has highly antiparasitic activity against Leishmania infantum (L. infantum) and Trypanosoma cruzi (T. cruzi) with IC50s of 7.28 μM and 2.30 μM, respectively. Antiparasitic agent-2 also has certain cytotoxicity against HepG2 (CC50 = 26.79 μM) [1].

Product Specifications

CAS Number

[2494277-80-2]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antiparasitic-agent-2.html

Solubility

10 mM in DMSO

Smiles

O=C1N(CC)C2=C(C=CC=C2)C1(O)C(C3=NC(C4=CC=CC=C4)=NO3)=C

Molecular Formula

C20H17N3O3

Molecular Weight

347.37

References & Citations

[1]Fernandes FS, et al. Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids. Eur J Med Chem. 2020;201:112418.