Topoisomerase IIα-IN-1
Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines[1].
Product Specifications
CAS Number
2407521-87-1
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-iiα-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=NC=CC=C2C(C(OC3=C4)=C1)=NC3=CC=C4C(N[C@H](C(O)=O)CCCCN)=O
Molecular Formula
C22H20N4O5
Molecular Weight
420.42
References & Citations
[1]Pedatella S, et al. Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new l-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors. Eur J Med Chem. 2020 Feb 1;187:111960.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
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