Topoisomerase IIα-IN-1

Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines[1].

Product Specifications

CAS Number

[2407521-87-1]

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-iiα-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=NC=CC=C2C(C(OC3=C4)=C1)=NC3=CC=C4C(N[C@H](C(O)=O)CCCCN)=O

Molecular Formula

C22H20N4O5

Molecular Weight

420.42

References & Citations

[1]Pedatella S, et al. Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new l-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors. Eur J Med Chem. 2020 Feb 1;187:111960.