HIV-1 protease-IN-4
HIV-1 protease-IN-4 (Compound II-22) is a potent HIV-1 protease inhibitor. HIV-1 protease-IN-4 is a proagent of atazanavir. HIV-1 protease-IN-4 as a proagent that delivers the parent 1 to rat plasma with a 5-fold higher AUC and 67-fold higher C24 when compared to oral administration of the parent agent[1].
Product Specifications
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hiv-1-protease-in-4.html
Solubility
10 mM in DMSO
Smiles
COC(N[C@@H](C(C)(C)C)C(N[C@@H](CC1=CC=CC=C1)[C@@H](OC(OC(OC([C@@H](N(C)C)C(C)C)=O)C)=O)CN(NC([C@H](C(C)(C)C)NC(OC)=O)=O)CC2=CC=C(C=C2)C3=CC=CC=N3)=O)=O
Molecular Formula
C48H69N7O11
Molecular Weight
920.10
References & Citations
[1]Subbaiah MAM, et al. (Carbonyl) oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration. Eur J Med Chem. 2020 Dec 1;207:112749.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
Frequently Asked Questions
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