Carbonic anhydrase inhibitor 13

Carbonic anhydrase inhibitor 13 (compound 7) is a potent carbonic anhydrase (CA) inhibitor, which features 3-methylthiazolo[3,2-a]benzimidazole moiety (as a tail) connected to the zinc anchoring benzenesulfonamide moiety via ureido linker[1].

Product Specifications

CAS Number

[2488872-31-5]

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/carbonic-anhydrase-inhibitor-13.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=C(NC(NC2=C(C)N3C4=CC=CC=C4N=C3S2)=O)C=C1)(N)=O

Molecular Formula

C17H15N5O3S2

Molecular Weight

401.46

References & Citations

[1]Alkhaldi AAM, et al. 3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies. Eur J Med Chem. 2020 Dec 1;207:112745.