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Tubulin/MMP-IN-1

Tubulin/MMP-IN-1 (compound 15g) is a potent inhibitor of tubulin and MMP. Tubulin/MMP-IN-1 has the potential for the research of cancer diseases. Tubulin/MMP-IN-1 suppresses tubulin polymerization, induces cell cycle arrest at the G2/M phase, leads to reactive oxidative stress (ROS) generation of HepG2 cells, and results in apoptosis by the mitochondrial-dependent apoptotic pathway[1].

Product Specifications

UNSPSC

12352005

Target

Microtubule/Tubulin; MMP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-mmp-in-1.html

Solubility

10 mM in DMSO

Smiles

CCOP(OCC)(C(C1=CC=CC=C1C)NC2=CC=C(C=C2)CC(OC3=CC(/C=C\C4=CC(OC)=C(C(OC)=C4)OC)=CC=C3OC)=O)=O

Molecular Formula

C38H44NO9P

Molecular Weight

689.73

References & Citations

[1]Yang L, et al. Dual-functional antitumor conjugates improving the anti-metastasis effect of combretastatin A4 by targeting tubulin polymerization and matrix metalloproteinases [published online ahead of print, 2022 May 5]. Eur J Med Chem. 2022;238:114439.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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