IDH2R140Q-IN-1
IDH2R140Q-IN-1 (compound C6) is a potent inhibitor of IDH2R140Q, with an IC50 of 6.1 nM. IDH2R140Q-IN-1 can be used for the research of acute myeloid leukemia[1].
Product Specifications
CAS Number
2469044-23-1
UNSPSC
12352005
Target
Isocitrate Dehydrogenase (IDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/idh2r140q-in-1.html
Solubility
10 mM in DMSO
Smiles
FC(C1=CC=CC(C2=NC(NCCCCCC3)=NC(NC4=CC3=CC(C(F)(F)F)=C4)=N2)=N1)(F)F
Molecular Formula
C22H20F6N6
Molecular Weight
482.42
References & Citations
[1]Che J, et, al. Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells. Eur J Med Chem. 2020 Oct 1;203:112491.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDH2
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
sc-423910-LAC 200 µL
Monoglyceride Lipase Lentiviral Activation Particles (m)
Sign In for Pricing
View Details 
MBS722250-04 10x 96 Well
Guinea pig Antithrombin receptor ELISA Kit
Sign In for Pricing
View Details