M7GpppGpG

M7GpppGpG, an oligonucleotide, is an M7GpppNpG trinucleotide cap analogue. m7GpppGpG prevents premature degradation by 5′-exonucleases and recruits proteins required for pre-mRNA splicing, mRNA transport and initiation of protein biosynthesis[1].

Product Specifications

CAS Number

133608-76-1

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/m7gpppgpg.html

Solubility

10 mM in DMSO

Smiles

O=P(O)(OC[C@@H]1[C@@H](OP(O)(OC[C@H]2O[C@@H](N3C(NC(N)=NC4=O)=C4N=C3)[C@H](O)[C@@H]2O)=O)[C@@H](O)[C@H](N5C(NC(N)=NC6=O)=C6N=C5)O1)OP(OP(OC[C@H]7O[C@@H](N8C(NC(N)=N9)=C([N+](C)=C8)C9=O)[C@H](O)[C@@H]7O)([O-])=O)(O)=O

Molecular Formula

C31H41N15O25P4

Molecular Weight

1147.64

References & Citations

[1]Sikorski PJ, et, al. The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells. Nucleic Acids Res. 2020 Feb 28;48 (4) :1607-1626.