M7GpppAmpG
M7GpppAmpG (m7G (5') ppp (5') (2'OMeA) pG) is a trinucleotide 5′ end cap analog. m7GpppAmpG binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG caps RNA with a capping efficiency of 90%. m7GpppAmpG enhances mRNA stability and translation efficiency. m7GpppAmpG is used in mRNA therapeutic research[1][2][3].
Product Specifications
CAS Number
62858-30-4
Product Name Alternative
M7G (5') ppp (5') (2'OMeA) pG
UNSPSC
12352005
Target
DNA/RNA Synthesis; Eukaryotic Initiation Factor (eIF)
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/m7gpppampg.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(OC[C@@H]1[C@@H](OP(O)(OC[C@H]2O[C@@H](N3C(NC(N)=NC4=O)=C4N=C3)[C@H](O)[C@@H]2O)=O)[C@@H](OC)[C@H](N5C=NC6=C(N)N=CN=C65)O1)OP(OP(OC[C@H]7O[C@@H](N8C(NC(N)=N9)=C([N+](C)=C8)C9=O)[C@H](O)[C@@H]7O)([O])=O)(O)=O
Molecular Formula
C32H43N15O24P4+
Molecular Weight
1145.66
References & Citations
[1]Sikorski PJ, Warminski M, Kubacka D, et al. The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells. Nucleic Acids Res. 2020;48 (4) :1607-1626. |[2]Zhang H, et al. GPT-Driven Generation and Biological Activity Evaluation of Novel mRNA Trinucleotide Cap1 Analogs for mRNA Vaccine or Immunotherapy. Journal of Materials Chemistry B, 2025.|[3]Raab M, et al. Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer. Cancer Commun (Lond) . 2024 Jan;44 (1) :101-126.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Isoform
EIF4
Frequently Asked Questions
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