β-S-ARCA

β-S-ARCA is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. mRNAs incorporating β-S-ARCA have elongated cellular half-lives and showed augmented protein expression. β-S-ARCA D1 has been applied in researching experimental mRNA-based anticancer vaccines[1].

Product Specifications

CAS Number

[1093268-63-3]

Product Name Alternative

3'-O-Me-m7G (5') ppp (5') G

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/β-s-arca.html

Solubility

10 mM in DMSO

Smiles

O=P(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O1)OP(OP(OC[C@@H]4[C@@H](O)[C@@H](OC)[C@H](N5C(NC(N)=N6)=C([N+](C)=C5)C6=O)O4)([O-])=O)(S)=O

Molecular Formula

C22H31N10O17P3S

Molecular Weight

832.52

References & Citations

[1]Warminski M, et al. Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect. ACS Chem Biol. 2021 Feb 19;16 (2) :334-343.