Divarasib (adipate)
Divarasib (GDC-6036) adipate is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of [1][2].
Product Specifications
CAS Number
2762240-36-6
Product Name Alternative
GDC-6036 (adipate)
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/divarasib-adipate.html
Purity
99.20
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=N[C@]([C@]2=C(C=C3C(N=C(N=C3N4[C@H](CN(CC4)C(C=C)=O)C)OC[C@H]5N(CCC5)C)=C2F)Cl)=C(C(C)=C1)C(F)(F)F.O=C(CCCCC(O)=O)O
Molecular Formula
C35H42ClF4N7O6
Molecular Weight
768.20
References & Citations
[1]Lingyao Meng, et al. Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach. Anal Chem. 2022 Sep 20;94 (37) :12927-12933.|[2]Sushant Malhotra, et al. Fused ring compounds. WO2020097537A2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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