(S, R) -CFT8634
(S, R) -CFT8634 (compound 176) is a selective and orally active PROTAC-class BRD9 protein degrader. (S, R) -CFT8634 has the potential to study BRD9-mediated diseases, including but not limited to abnormal cell proliferation. (S, R) -CFT8634 consists of a target protein ligand (red part) BRD9 ligand-5 , an E3 ligase ligand (blue part) CRBN ligand-11 (HY-169989), and a PROTAC linker (black part) 1- (3,3-Difluoro-4-piperidinyl) piperazine (HY-169991). E3 ligase ligand and linker can form E3 Ligase Ligand-linker Conjugate 142 (HY-169990).
Product Specifications
CAS Number
2704617-95-6
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-cft8634.html
Solubility
10 mM in DMSO
Smiles
CC(C(C1=CC(OC)=C(C(OC)=C1)CN2CC(F)([C@@H](N3CCN(C4=C(C=C(C=C4)N[C@H]5C(NC(CC5)=O)=O)F)CC3)CC2)F)=CN6C)=C(C)C6=O
Molecular Formula
C37H45F3N6O5
Molecular Weight
710.79
References & Citations
[1]Christopher G. Nasveschuk, et al. Compounds for targeted degradation of brd9. Patent WO2021178920A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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