ChemR23-IN-3
ChemR23-IN-3 is a potent thiazole-based ChemR23 inhibitor with an IC80 value of 12 nM.
Product Specifications
CAS Number
[3032433-98-7]
UNSPSC
12352005
Target
Chemerin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/chemr23-in-3.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C(NO2)=NC2=O)C(C(C=C3)=CC=C3[C@@H](C)N(CC4CC4)C5=NC(C(NS(C6CC6)(=O)=O)=O)=C(C7CC7)S5)=C1
Molecular Formula
C31H33N5O5S2
Molecular Weight
619.75
References & Citations
[1]Imaizumi T, et al. Discovery and mechanistic study of thiazole-4-acylsulfonamide derivatives as potent and orally active ChemR23 inhibitors with a long-acting effect in cynomolgus monkeys. Bioorg Med Chem. 2022 Feb 15;56:116587.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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