P53-HDM2-IN-1

P53-HDM2-IN-1 is a potent inhibitor of p53-HDM2 protein-protein interaction, with an IC50 of 0.103 μM. p53-HDM2-IN-1 can be used for the research of cancer[1].

Product Specifications

UNSPSC

12352005

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/p53-hdm2-in-1.html

Solubility

10 mM in DMSO

Smiles

CCC[C@H]1N(CCC[C@@]1(OC2=CSC(C(F)(F)F)=C2)C(N3CCN(CC3)C4=CC=CC=C4OCCCC(O)=O)=O)C(C5=C(C=CN=C5O)C(F)(F)F)=O

Molecular Formula

C35H38F6N4O7S

Molecular Weight

772.75

References & Citations

[1]Tian Y, et, al. Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability. Bioorg Med Chem Lett. 2022 Apr 1;61:128625.