P53-HDM2-IN-1
P53-HDM2-IN-1 is a potent inhibitor of p53-HDM2 protein-protein interaction, with an IC50 of 0.103 μM. p53-HDM2-IN-1 can be used for the research of cancer[1].
Product Specifications
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p53-hdm2-in-1.html
Solubility
10 mM in DMSO
Smiles
CCC[C@H]1N(CCC[C@@]1(OC2=CSC(C(F)(F)F)=C2)C(N3CCN(CC3)C4=CC=CC=C4OCCCC(O)=O)=O)C(C5=C(C=CN=C5O)C(F)(F)F)=O
Molecular Formula
C35H38F6N4O7S
Molecular Weight
772.75
References & Citations
[1]Tian Y, et, al. Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability. Bioorg Med Chem Lett. 2022 Apr 1;61:128625.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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