D4R antagonis-2

D4R antagonist-2 is a potent and selective D4R antagonist with an IC50 of 6.52 μM. D4R antagonist-2 displays very favorable in vitro PK parameters and has good brain penetration. D4R antagonist-2 has the potential for the research of Parkinson’s disease[1].

Product Specifications

CAS Number

[2846077-70-9]

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d4r-antagonis-2.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C=CC=C1NC(CN2CCC(CC2)OCC3=CC=C(C(F)=C3)F)=O)Cl

Molecular Formula

C21H23ClF2N2O2

Molecular Weight

408.87

References & Citations

[1]Tolentino KT, et al. Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists. Bioorg Med Chem Lett. 2022; 61:128615.