D4R antagonis-2
D4R antagonist-2 is a potent and selective D4R antagonist with an IC50 of 6.52 μM. D4R antagonist-2 displays very favorable in vitro PK parameters and has good brain penetration. D4R antagonist-2 has the potential for the research of Parkinson’s disease[1].
Product Specifications
CAS Number
[2846077-70-9]
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/d4r-antagonis-2.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C=CC=C1NC(CN2CCC(CC2)OCC3=CC=C(C(F)=C3)F)=O)Cl
Molecular Formula
C21H23ClF2N2O2
Molecular Weight
408.87
References & Citations
[1]Tolentino KT, et al. Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists. Bioorg Med Chem Lett. 2022; 61:128615.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D4 Receptor
Curated Selection
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