PDGFRα/FLT3-ITD-IN-1
PDGFRα/FLT3-ITD-IN-1 (Compound 12d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia[1].
Product Specifications
CAS Number
2761259-05-4
UNSPSC
12352005
Target
FLT3; PDGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pdgfrα-flt3-itd-in-1.html
Solubility
10 mM in DMSO
Smiles
NCCCCNC(C1=CC=C(C=C1)NC2=NC(N[C@@H]3CC[C@H](CC3)N)=NC4=C2N=CN4C5CCCC5)=O
Molecular Formula
C27H39N9O
Molecular Weight
505.66
References & Citations
[1] Vlková K, et al. Synthesis and biological activity evaluation of novel 2,6,9-trisubstituted purine conjugates as potential protein kinases inhibitors. Bioorg Med Chem Lett. 2022 Mar 15;60:128603
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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