TLR7/8 agonist 6
TLR7/8 agonist 6 (Compound 4) is the potent agonist of TLR7/8 with IC50s of 0.18 and 5.34 μM, respectively. TLR7/8 agonist 6 is an imidazoquinoline derivative compound. Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for researching infectious disease, cancer, and autoimmune disorders[1].
Product Specifications
CAS Number
2115702-83-3
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr7-8-agonist-6.html
Purity
98.93
Solubility
DMSO : 20 mg/mL (ultrasonic; heat to 60°C)
Smiles
CCCCC1=NC2=C(N=C3C=C(C=CC3=C2N1CC4=CC=C(CN)C=C4)C(OC)=O)N
Molecular Formula
C24H27N5O2
Molecular Weight
417.50
References & Citations
[1]Yang M, et al. Toll-like receptor 7 and 8 imidazoquinoline-based agonist/antagonist pairs. Bioorg Med Chem Lett. 2022;59:128548.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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