BTK-IN-8
BTK-IN-8 is a potent and selective peripheral covalent BTK inhibitor (IC50=0.22 nM; Kd=0.91 nM) . BTK-IN-8 has good whole blood CD69 cellular potency (IC50=0.029 μM) [1].
Product Specifications
CAS Number
2824922-28-1
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/btk-in-8.html
Solubility
10 mM in DMSO
Smiles
CC(C)CN(CC1=O)CCN1CC(C(C)=C2)=CC=C2C(N=CN=C3N)=C3OCCN(C)C(C=C)=O
Molecular Formula
C26H36N6O3
Molecular Weight
480.60
References & Citations
[1]Ma B, et al. Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors. Bioorg Med Chem Lett. 2022, 60:128549.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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