BTK-IN-8
Product Specifications
UNSPSC Description
BTK-IN-8 is a potent and selective peripheral covalent BTK inhibitor (IC50=0.22 nM; Kd=0.91 nM). BTK-IN-8 has good whole blood CD69 cellular potency (IC50=0.029 μM)[1].
Target Antigen
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/btk-in-8.html
Solubility
10 mM in DMSO
Smiles
CC(C)CN(CC1=O)CCN1CC(C(C)=C2)=CC=C2C(N=CN=C3N)=C3OCCN(C)C(C=C)=O
Molecular Weight
480.60
References & Citations
[1]Ma B, et al. Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors. Bioorg Med Chem Lett. 2022, 60:128549.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145884/BTK-IN-8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145884/
Clinical Information
No Development Reported
CAS Number
2824922-28-1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
24973141 1x10<sup>6</sup> cells/1.0ml
INO80B CRISPR Knock Out 293T Cell Line (Human)
Ask
View Details