BTK-IN-8

BTK-IN-8 is a potent and selective peripheral covalent BTK inhibitor (IC50=0.22 nM; Kd=0.91 nM) . BTK-IN-8 has good whole blood CD69 cellular potency (IC50=0.029 μM) [1].

Product Specifications

CAS Number

[2824922-28-1]

UNSPSC

12352005

Target

Btk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/btk-in-8.html

Solubility

10 mM in DMSO

Smiles

CC(C)CN(CC1=O)CCN1CC(C(C)=C2)=CC=C2C(N=CN=C3N)=C3OCCN(C)C(C=C)=O

Molecular Formula

C26H36N6O3

Molecular Weight

480.60

References & Citations

[1]Ma B, et al. Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors. Bioorg Med Chem Lett. 2022, 60:128549.