EGFR-IN-45
Product Specifications
UNSPSC Description
EGFR-IN-45 is a potent epidermal growth factor receptor (EGFR) pan inhibitor, with IC50s of 0.4 μM and 1.6 μM for EGFR and CDK2, respectively. EGFR-IN-45 also inhibit Topo I and Topo II. EGFR-IN-45 arrests cancer cells in the pre-G1 phase and induces apoptosis[1].
Target Antigen
Apoptosis; CDK; EGFR; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-45.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(C2=CC=CC=C2)=NC3=C1C(NC4=CC=CC=C43)=NC5=C(C)N(C)N(C6=CC=CC=C6)C5=O
Molecular Weight
473.53
References & Citations
[1]Mekheimer RA, Allam SMR, Al-Sheikh MA, et al. Discovery of new pyrimido[5,4-c]quinolines as potential antiproliferative agents with multitarget actions: Rapid synthesis, docking, and ADME studies. Bioorg Chem. 2022;121:105693.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145867/EGFR-IN-45-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145867/
Clinical Information
No Development Reported
CAS Number
2765560-03-8
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