EGFR-IN-45

EGFR-IN-45 is a potent epidermal growth factor receptor (EGFR) pan inhibitor, with IC50s of 0.4 μM and 1.6 μM for EGFR and CDK2, respectively. EGFR-IN-45 also inhibit Topo I and Topo II. EGFR-IN-45 arrests cancer cells in the pre-G1 phase and induces apoptosis[1].

Product Specifications

CAS Number

[2765560-03-8]

UNSPSC

12352005

Target

Apoptosis; CDK; EGFR; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-45.html

Solubility

10 mM in DMSO

Smiles

NC1=NC(C2=CC=CC=C2)=NC3=C1C(NC4=CC=CC=C43)=NC5=C(C)N(C)N(C6=CC=CC=C6)C5=O

Molecular Formula

C28H23N7O

Molecular Weight

473.53

References & Citations

[1]Mekheimer RA, Allam SMR, Al-Sheikh MA, et al. Discovery of new pyrimido[5,4-c]quinolines as potential antiproliferative agents with multitarget actions: Rapid synthesis, docking, and ADME studies. Bioorg Chem. 2022;121:105693.