c-Met/MEK1/Flt-3-IN-1
Product Specifications
UNSPSC Description
Antiproliferative against-3 (comp 33) shows a prominent activity against Hela (IC50 = 0.21 µM), A549 (IC50 = 0.39 µM), and MCF-7 (IC50 = 0.33 µM), respectively. Antiproliferative against-3 (comp 33) also dose dependently induces apoptosis by arresting A549 cells at G1 phase[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-mek1-flt-3-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2N=CC=C(C2=C1)OC3=CC=C(C=C3)NC(C4=CN(C5=C(C4=O)C=CC=N5)C6=CC=C(C=C6)F)=O)OCCCN7CCN(CC7)C
Molecular Weight
688.75
References & Citations
[1]Pengqin Chen, et al. Design, synthesis and anticancer evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 1,8-naphthyridine-3-carboxamide moiety as novel multi-target TKIs. Bioorg Chem. 2022 Apr;121:105672.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145865/c-Met-MEK1-Flt-3-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145865/
Clinical Information
No Development Reported
Curated Selection
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