C-Met/MEK1/Flt-3-IN-1

Antiproliferative against-3 (comp 33) shows a prominent activity against Hela (IC50 = 0.21 µM), A549 (IC50 = 0.39 µM), and MCF-7 (IC50 = 0.33 µM), respectively. Antiproliferative against-3 (comp 33) also dose dependently induces apoptosis by arresting A549 cells at G1 phase[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/c-met-mek1-flt-3-in-1.html

Solubility

10 mM in DMSO

Smiles

COC1=C(C=C2N=CC=C(C2=C1)OC3=CC=C(C=C3)NC(C4=CN(C5=C(C4=O)C=CC=N5)C6=CC=C(C=C6)F)=O)OCCCN7CCN(CC7)C

Molecular Formula

C39H37FN6O5

Molecular Weight

688.75

References & Citations

[1]Pengqin Chen, et al. Design, synthesis and anticancer evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 1,8-naphthyridine-3-carboxamide moiety as novel multi-target TKIs. Bioorg Chem. 2022 Apr;121:105672.