VEGFR-2-IN-12
VEGFR-2-IN-12 (compound 6g), a 2-oxoquinoxalinyl-1,2,4-triazole, is a potent VEGFR-2 inhibitor with an IC50 of 0.037 µM. VEGFR-2-IN-12 shows high growth inhibition against MCF-7 cells (GI50=1.6 µM) . VEGFR-2-IN-12 has antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-12.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)NC(CSC2NN=C(N2C)CN3C(C(C)=NC4=CC=CC=C43)=O)=O
Molecular Formula
C22H24N6O3S
Molecular Weight
452.53
References & Citations
[1]Merve Zengin, et al. Design and synthesis of new 2-oxoquinoxalinyl-1,2,4-triazoles as antitumor VEGFR-2 inhibitors. Bioorg Chem. 2022 Apr;121:105696.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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