5-HT6/5-HT2AR antagonist-1
5-HT6/5-HT2AR antagonist-1 is a potent dual 5-HT6/5-HT2AR antagonist with Ki values of 11 nM and 39 nM, respectively[1].
Product Specifications
CAS Number
2763654-60-8
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-ht6-5-ht2ar-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(N2CCN(C)CC2)=NC(C(C)(SC3=CC=C4C=CC=CC4=C3)C)=N1
Molecular Formula
C21H26N6S
Molecular Weight
394.54
References & Citations
[1]Katarzyna Kucwaj-Brysz, et al. An exit beyond the pharmacophore model for 5-HT 6 R agents - a new strategy to gain dual 5-HT 6/5-HT 2A action for triazine derivatives with procognitive potential. Bioorg Chem. 2022 Apr;121:105695.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT6 Receptor; MUC2; α-1 microglobulin
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