PHGDH-IN-2
PHGDH-IN-2 is a potent and NAD+ competitive PHGDH inhibitor with an IC50 of 5.2 μM. PHGDH-IN-2 inhibits the serine synthetic pathway in MDA-MB-468 cells. PHGDH-IN-2 inhibits the growth of PHGDH-dependent cancer cells[1].
Product Specifications
UNSPSC
12352005
Target
Phosphoglycerate Dehydrogenase (PHGDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phgdh-in-2.html
Solubility
10 mM in DMSO
Smiles
CN1C(C(NC2=CC=CC(NS(=O)(C3=CC=C(C=C3)N)=O)=C2)=O)=CC4=C1C=CC=C4
Molecular Formula
C22H20N4O3S
Molecular Weight
420.48
References & Citations
[1]Zhang FM, et al. Discovery of PHGDH inhibitors by virtual screening and preliminary structure-activity relationship study. Bioorg Chem. 2022, 121:105705.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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