J-1063
J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC50 of 0.039 μM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis[1].
Product Specifications
CAS Number
2374772-46-8
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/j-1063.html
Solubility
10 mM in DMSO
Smiles
CC1=NC(C2=NN(C=C2C3=CC4=C(S3)C=CN=C4)CC(NC5=CC=CC=C5)=O)=CC=C1
Molecular Formula
C24H19N5OS
Molecular Weight
425.51
References & Citations
[1]Zheng GH, et al. The in vitro and in vivo study of a pyrazole derivative, J-1063, as a novel anti-liver fibrosis agent: Synthesis, biological evaluation, and mechanistic analysis. Bioorg Chem. 2022; 122:105715.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALK5
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