GA-O-02

GA-O-02, a 18β-Glycyrrhetinic acid derivative, is a potent antimicrobial and anti-inflammatory agent. GA-O-02 exerts anti-inflammation through the inhibition of NO, pro-inflammatory cytokines and chemokines. GA-O-02 displays a high antimicrobial activity against Gram-positive bacteria[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ga-o-02.html

Solubility

10 mM in DMSO

Smiles

C[C@@]1(C(O)=O)C[C@]2([H])[C@@](C)(CC[C@@]3(C2=CC([C@@]4([C@]5(C/C(C(C(C)([C@@]5(CC[C@@]34C)[H])C)=O)=C\C6=C(C=C(C=C6)Cl)[N+]([O-])=O)C)[H])=O)C)CC1

Molecular Formula

C37H46ClNO6

Molecular Weight

636.22

References & Citations

[1]Borong Tu, et al. Novel 18β-glycyrrhetinic acid derivatives as a Two-in-One agent with potent antimicrobial and anti-inflammatory activity. Bioorg Chem. 2022 May;122:105714.